1.9 million neurons die every minute during ischaemic stroke without reperfusion. Time targets: Door-to-CT: <25 min | Door-to-needle (tPA): <60 min | Door-to-groin (thrombectomy): <90 min
Immediate Actions — STROKE Bundle
Airway: Protect airway; intubate only if GCS ≤8 or respiratory compromise
Glucose: Immediate bedside BGL — treat hypoglycaemia (<3.5 mmol/L) with 50% dextrose IV. DO NOT aggressively treat hyperglycaemia unless >14 mmol/L
CT head: Non-contrast CT within 25 minutes — exclude haemorrhage before thrombolysis
Onset time: Document exact time of last-known-well (LKW) — critical for thrombolysis eligibility
NIHSS assessment: Trained nurse scores within minutes of arrival
Notify stroke team: Pre-alert on arrival at ED via ambulance call
BP Management in Acute Stroke
Do NOT aggressively lower BP in acute ischaemic stroke — penumbra depends on elevated BP. Only treat if: BP >220/120 (ischaemic, no thrombolysis) OR >185/110 (if thrombolysis planned) OR in haemorrhagic stroke (target SBP <140 mmHg within 1 hr).
Scenario
BP Target
Drug
Ischaemic, no thrombolysis
Only treat if >220/120
Labetalol IV; nicardipine
Ischaemic, pre-thrombolysis
Bring to ≤185/110 before tPA
Labetalol 10–20 mg IV
Ischaemic, post-thrombolysis 24 hrs
Maintain <180/105
Labetalol or nicardipine infusion
Haemorrhagic
SBP ≤140 within 1 hr
Labetalol, nicardipine, clevidipine
NIHSS — National Institutes of Health Stroke Scale
The NIHSS is a 15-item neurological examination scoring 0–42. Higher scores = more severe stroke.
Indicated for large vessel occlusion (LVO — internal carotid, proximal MCA) up to 24 hrs in selected patients
Superior to tPA alone for LVO — number needed to treat = 2.6 for functional independence
Requires CT angiography to confirm LVO before transfer to interventional centre
Available at major GCC stroke centres: KFSH&RC, Cleveland Clinic Abu Dhabi, HMC Qatar
Post-Stroke Nursing Care
Swallowing Assessment — CRITICAL
NIL BY MOUTH until swallow screen completed. Dysphagia affects 40–70% of acute stroke patients. Aspiration pneumonia is a leading cause of post-stroke death.
Bedside swallow screen (water test or standardised tool) within 4 hours of admission
If swallow screen FAILS → NPO, insert NG tube for medications and nutrition, refer to speech and language therapist (SLT)
Formal swallowing assessment by SLT within 24–48 hours
Medications: crush or liquid formulations only if swallow impaired; NG/PEG for long-term dysphagia
NG tube placement confirmation: CXR or pH <5.5 aspirate — NEVER use auscultation alone
Target normothermia; treat fever >37.5°C with paracetamol
SpO₂
Continuous
Target ≥94%; supplemental O₂ only if SpO₂ <94%
Urine output / hydration
Hourly
IV fluids: 0.9% NaCl; avoid glucose IV (worsens ischaemia)
Secondary Prevention
Antiplatelets: Aspirin 300 mg loading, then 75 mg daily (start 24 hrs post-tPA; immediately if no thrombolysis). Clopidogrel + aspirin dual therapy for 21 days in minor stroke/high-risk TIA
Statins: High-intensity statin (atorvastatin 80 mg) initiated on day 1 — LDL target <1.8 mmol/L
Anticoagulation in AF: Start DOAC 3–14 days post-stroke (timing based on infarct size)
Blood pressure: Start/resume antihypertensives after 24–48 hrs stability
Early rehabilitation: Mobilisation within 24 hrs (unless contraindicated); physiotherapy, OT, SLT within 48 hrs
GCC-Specific Context
Stroke in GCC Populations
Younger stroke patients: GCC sees a higher proportion of stroke in patients under 50 — linked to uncontrolled diabetes, hypertension, dyslipidaemia, smoking and metabolic syndrome
Sickle cell disease: Higher prevalence in GCC (especially Oman, Bahrain) — sickle cell stroke may affect children and young adults; managed differently (exchange transfusion)
Cardiac embolism: Rheumatic mitral stenosis with AF — still prevalent in GCC migrant workers from endemic regions — a common cause of embolic stroke
Thrombophilia: Factor V Leiden and other thrombophilias are more prevalent in consanguineous GCC families — higher rate of cerebral venous sinus thrombosis (CVST) especially in young women postpartum
Language barriers: NIHSS administration requires trained Arabic/multilingual assessors in GCC stroke units — critical for accurate scoring in non-English-speaking patients
Key Exam Tips — DHA/SCFHS/QCHP
"Time is brain" — 1.9 million neurons/minute — classic exam opener
tPA dose: 0.9 mg/kg, max 90 mg; 10% bolus + 90% over 60 min
tPA window: 4.5 hours from onset/last known well
BP pre-tPA: must be ≤185/110 before starting
Haemorrhagic stroke = absolute contraindication to tPA
Swallowing screen BEFORE any oral intake or medications
IV fluid in stroke: 0.9% NaCl (not glucose — worsens ischaemic injury)
Glucose <3.5 mmol/L mimics stroke — ALWAYS check BGL first
Exam MCQs — DHA / SCFHS / QCHP
Q1. A patient presents with sudden onset left arm weakness and facial drooping. Onset was 2 hours ago. CT head shows no haemorrhage. BP is 178/104 mmHg. What is the NEXT priority action?
✅ C — Patient is within 4.5-hour window, CT excludes haemorrhage, BP is ≤185/110 (acceptable). tPA is the priority intervention. Aspirin is withheld for 24 hrs post-tPA. LMWH is NOT used in acute ischaemic stroke management acutely.
Q2. A nurse is caring for an acute stroke patient on a general medical ward. The patient is drowsy and unable to cooperate with a swallowing assessment. What action is CORRECT?
✅ C — An uncooperative or drowsy stroke patient CANNOT be safely assessed for swallowing. Keep nil by mouth, insert NG tube for medications and nutrition, and refer to SLT urgently. Aspiration pneumonia kills post-stroke patients.
Q3. During alteplase infusion for acute ischaemic stroke, the nurse notes the patient's GCS drops from 14 to 9 and BP rises to 205/120. What is the IMMEDIATE action?
✅ B — Neurological deterioration during tPA = suspect haemorrhagic transformation. STOP infusion immediately, call stroke team, urgent CT head. Prepare for reversal (cryoprecipitate 10 units, ± FFP, ± platelets). Do NOT continue infusion or attribute deterioration to expected side effects.
Q4. Which IV fluid is CONTRAINDICATED in acute ischaemic stroke management?
✅ B — Glucose-containing fluids are contraindicated in ischaemic stroke. Hyperglycaemia worsens cerebral ischaemic injury through anaerobic metabolism, increased acidosis and oedema. Use 0.9% NaCl as the standard maintenance fluid.