📊 Age-Based Normal Vital Signs
| Age Group | HR (bpm) | RR (breaths/min) | Systolic BP (mmHg) | SaO₂ (%) |
|---|---|---|---|---|
| Neonate (0–1 mo) | 100–160 | 40–60 | 60–90 | ≥95 |
| Infant (1–12 mo) | 100–160 | 30–60 | 70–100 | ≥95 |
| Toddler (1–3 yr) | 90–150 | 24–40 | 80–110 | ≥95 |
| Preschool (3–5 yr) | 80–140 | 22–34 | 80–110 | ≥95 |
| School (6–12 yr) | 70–120 | 18–30 | 85–120 | ≥95 |
| Adolescent (>12 yr) | 60–100 | 12–20 | 90–130 | ≥95 |
🚨 PEWS — Paediatric Early Warning Score
Scores 0–3 in each domain. Total ≥4 = escalate; ≥6 = consider PICU referral immediately.
| Domain | 0 | 1 | 2 | 3 |
|---|---|---|---|---|
| Behaviour | Playing/Appropriate | Sleeping | Irritable | Lethargic/Confused |
| Cardiovascular | Pink, CRT <2s | Pale, CRT 3s | Grey, CRT 4s | Grey/mottled, CRT ≥5s |
| Respiratory | Normal rate, no recession | RR+10, mild recession | RR+20, moderate recession | 5+ below normal or sternal recession |
| Nebuliser/O₂ | None | — | 4+ L/min O₂ | ≥50% O₂ or hourly neb |
| Vomiting post-op | None | 1× | 2× | ≥3× / bilious |
📈 PRISM-III Score Overview
Paediatric Risk of Mortality III — calculated in first 12 hours of PICU admission. Predicts risk of death.
Variables Assessed (17 total)
- Systolic BP (age-specific ranges)
- Temperature (>40°C or <33°C = high risk)
- Mental status (GCS adaptation)
- Heart rate (age-specific)
- Pupillary reflexes (abnormal = 4–7 pts)
- PT, PTT, total bilirubin
- Potassium, calcium, glucose, bicarbonate
- PCO₂, PaO₂/FiO₂ ratio
- Creatinine (age-adjusted)
👨👩👧 Family-Centred Care Principles in PICU
Dignity & Respect
- Listen to family knowledge of the child
- Honour cultural and religious values
- Avoid terminology that diminishes family role
- Individualise care to family preferences
Information Sharing
- Daily family briefings from senior nurse or physician
- Use interpreters when Arabic/English barrier exists
- Written summaries of plan of care
- Honest, timely communication at all stages
Participation
- Invite family in ward rounds where appropriate
- Encourage comfort touch, reading to child
- Teach suctioning/NG care to willing parents
- Family presence during procedures — supported
🔤 WETFLAG — Emergency Drug Dosing Mnemonic
| Letter | Parameter | Formula | Notes |
|---|---|---|---|
| W | Weight (kg) | (Age + 4) × 2 for 1–10 yr | Or use Broselow tape; neonates use actual weight |
| E | Energy (Joules) | 4 J/kg | Biphasic defibrillation; max 200 J |
| T | Tube (ETT size, mm) | (Age/4) + 4 uncuffed; (Age/4) + 3.5 cuffed | Have size above and below available |
| F | Fluid (mL) | 20 mL/kg bolus (sepsis); 10 mL/kg in shock with cardiac risk | Reassess after each bolus |
| L | Lorazepam (mg) | 0.1 mg/kg IV | Max 4 mg; for seizures |
| A | Adrenaline (mL of 1:10,000) | 0.1 mL/kg IV/IO | = 0.01 mg/kg; repeat every 3–5 min in arrest |
| G | Glucose (mL of 10%) | 2 mL/kg of 10% glucose | For hypoglycaemia; recheck BG 15 min after |
🫁 Cuffed vs Uncuffed ETT Selection
Uncuffed ETT (traditional guidance)
- Preferred in children <8 years (narrow cricoid = natural seal)
- Less risk of subglottic mucosal injury
- Leak pressure should be 20–25 cmH₂O (if using uncuffed)
Cuffed ETT (current evidence-based)
- Now safe and preferred in PICU even for infants
- Allows better ventilation control, reduced contamination
- Cuff pressure: maintain 20–25 cmH₂O (use manometer)
- Formula: size = (Age/4) + 3.5; or 0.5 less than uncuffed
⚙️ Paediatric Ventilation Settings
Standard Initial Settings
| Parameter | Target |
|---|---|
| Tidal Volume (Vt) | 6–8 mL/kg IBW (lung protective) |
| PEEP | 5–8 cmH₂O (start 5; increase for hypoxia) |
| FiO₂ | Titrate to SaO₂ 94–98% |
| Rate | Age-appropriate (≈ normal RR) |
| Peak Pressure | <30 cmH₂O (avoid barotrauma) |
| I:E Ratio | 1:2 standard; 1:3–4 in obstruction (asthma) |
| Target PaCO₂ | 35–45 mmHg (allow permissive hypercapnia in ARDS) |
🌀 High-Frequency Oscillatory Ventilation (HFO)
Indications
- Severe ARDS refractory to conventional ventilation
- Oxygenation Index (OI) >20–40
- Air leak syndromes (PIE, pneumothorax)
- Persistent pulmonary hypertension of newborn (PPHN)
Key Parameters
- MAP: Start 2–3 cmH₂O above conventional MAP
- Frequency: 8–15 Hz (lower = more CO₂ clearance)
- Amplitude (ΔP): Titrate to chest "wiggle" to umbilicus
- FiO₂: Wean as oxygenation improves
💨 High-Flow Nasal Cannula (HFNC) in Children
Indications
- Bronchiolitis (first-line after standard O₂ fails)
- Mild-moderate respiratory failure
- Post-extubation support
- Severe pneumonia — bridge to intubation decision
Flow Rates
| Age | Starting Flow | Max Flow |
|---|---|---|
| Neonate | 2–4 L/min | 6 L/min |
| Infant | 4–8 L/min | 2 L/kg/min |
| Child | 1 L/kg/min | 40–50 L/min |
💉 Vasoactive Infusions
| Drug | Dose Range | Notes |
|---|---|---|
| Dopamine | 5–20 mcg/kg/min | 5–10: inotropic; >10: vasopressor |
| Dobutamine | 5–20 mcg/kg/min | Inotropic; no significant vasopressor effect |
| Noradrenaline | 0.05–2 mcg/kg/min | Start 0.05–0.1; vasopressor of choice in warm shock |
| Adrenaline | 0.05–1 mcg/kg/min | Cold shock / cardiac arrest; high doses → tachycardia |
| Milrinone | 0.25–0.75 mcg/kg/min | Post-cardiac surgery; PDE-3 inhibitor; no loading in PICU |
| Vasopressin | 0.0003–0.002 units/kg/min | Refractory septic shock; catecholamine-sparing |
💊 Sedation & Analgesia
| Drug | Bolus | Infusion |
|---|---|---|
| Midazolam | 0.05–0.1 mg/kg IV | 0.02–0.1 mg/kg/hr (max 0.4) |
| Morphine | 0.05–0.1 mg/kg IV | 10–40 mcg/kg/hr |
| Fentanyl | 1–2 mcg/kg IV | 1–4 mcg/kg/hr |
| Dexmedetomidine | Avoid loading in PICU | 0.2–1.4 mcg/kg/hr (titrate) |
| Ketamine | 1–2 mg/kg IV (procedural) | 0.1–0.5 mg/kg/hr (analgesia) |
| Propofol | 1–2 mg/kg IV (induction) | Avoid infusion >4 hrs in children (PRIS risk) |
| Chloral hydrate | 25–50 mg/kg PO/PR | Procedural sedation; max 100 mg/kg |
🧠 Paralytic Agents (Neuromuscular Blockade)
| Drug | Type | Dose | Duration |
|---|---|---|---|
| Suxamethonium | Depolarising | 1–2 mg/kg IV (infant: 2 mg/kg) | 5–10 min |
| Rocuronium | Non-depol | 0.6–1.2 mg/kg IV | 30–60 min |
| Vecuronium | Non-depol | 0.1 mg/kg IV bolus | 25–40 min |
| Vecuronium infusion | Non-depol | 0.05–0.1 mg/kg/hr | Continuous |
| Atracurium | Non-depol | 0.5 mg/kg IV; 5–10 mcg/kg/min | 20–35 min |
| Sugammadex | Reversal | 2–4 mg/kg IV (routine reversal) | Immediate |
⚡ Emergency Drugs
| Drug | Dose | Indication |
|---|---|---|
| Adrenaline 1:10,000 | 0.1 mL/kg IV/IO | Cardiac arrest; anaphylaxis 0.01 mg/kg IM |
| Atropine | 0.02 mg/kg IV (min 0.1 mg) | Bradycardia; pre-intubation in infants |
| Adenosine | 0.1 mg/kg rapid IV (max 6 mg first dose) | SVT; escalate to 0.2 then 0.3 mg/kg |
| Amiodarone | 5 mg/kg IV over 20 min (VT/VF: 5 mg/kg rapid) | Pulseless VT/VF, SVT |
| Sodium bicarbonate | 1 mmol/kg slow IV (8.4% = 1 mL/kg; dilute 1:1) | Severe metabolic acidosis, hyperkalaemia |
| Calcium gluconate 10% | 0.5–1 mL/kg IV slowly | Hypocalcaemia, hyperkalaemia, CCB toxicity |
| Naloxone | 0.01 mg/kg IV (titrate to effect) | Opioid reversal |
| Flumazenil | 0.01 mg/kg IV (max 0.2 mg) | Benzo reversal — use cautiously |
🧬 Anticonvulsant Ladder
| Step | Drug | Dose | Route | Timing |
|---|---|---|---|---|
| 1st | Diazepam | 0.2–0.5 mg/kg (max 10 mg) | IV / PR | 0–5 min; may repeat once |
| 1st | Lorazepam | 0.1 mg/kg IV (max 4 mg) | IV / IN | Preferred if IV access |
| 1st | Midazolam | 0.2 mg/kg buccal; 0.1 mg/kg IV | Buccal / IV / IM | Prehospital first-line |
| 2nd | Levetiracetam | 40–60 mg/kg IV (max 3 g) | IV over 5–15 min | 5–20 min post-benzo |
| 2nd | Phenytoin / Fosphenytoin | 20 mg/kg IV (max 1 g) | IV over 20 min (monitor ECG) | Alternative 2nd line |
| 2nd | Phenobarbitone | 20 mg/kg IV (max 1 g) | IV over 20–30 min | Neonates — 1st choice 2nd agent |
| 3rd | Thiopental sodium | 2–5 mg/kg IV; infusion 1–5 mg/kg/hr | IV — needs intubation | Refractory status |
| 3rd | Midazolam infusion | 0.05–0.4 mg/kg/hr | IV continuous | Refractory status |
🦠 Paediatric Septic Shock (PALS Algorithm)
Recognition (within 1 hour)
- Fever/hypothermia + altered mental status
- Warm shock: flash CRT, bounding pulse, wide pulse pressure
- Cold shock: prolonged CRT (>3s), weak pulse, mottled
- Lactate >2 mmol/L or >4 mmol/L = severe
Management Bundle
- Fluid: 10–20 mL/kg isotonic boluses; reassess after each. Caution if signs of fluid overload (rales, hepatomegaly). Up to 40–60 mL/kg in 1st hour without cardiac disease
- Antibiotics: Within 1 hour of recognition — broad spectrum empirical
- Vasopressor: Cold shock → Adrenaline (start 0.05 mcg/kg/min); Warm shock → Noradrenaline (start 0.05 mcg/kg/min)
- Corticosteroids: Hydrocortisone 1–2 mg/kg Q6H if catecholamine-resistant shock
- Target: MAP ≥ (age × 1.5 + 40); ScvO₂ ≥70%; lactate normalisation
⚡ Status Epilepticus
- Definition: seizure >5 minutes or recurrent without recovery
- Refractory: persisting >30 min despite 2 agents
Immediate Actions
- Airway, O₂ — suction, nasal airway if needed
- BGL — if low give 10% glucose 2 mL/kg
- ECG, temperature, Na, Ca, Mg levels
- EEG monitoring once stabilised
Follow anticonvulsant ladder (see Drug tab)
EEG Monitoring Targets
- Burst suppression ratio 50–90% in refractory SE
- Continuous cEEG if paralysed (detect subclinical seizures)
- Wean sedation/AEDs gradually when seizure-free 24–48 hrs
🍬 Paediatric DKA Management
Criteria
- BGL >11 mmol/L + ketones >3 mmol/L or ketonuria
- pH <7.3 or bicarbonate <15 mmol/L
- Severity: Mild (pH 7.2–7.3), Moderate (7.1–7.2), Severe (<7.1)
Fluid Management (ISPAD 2022)
- Restoration only if shocked: 10 mL/kg 0.9% NaCl over 30 min
- Replace deficit + maintenance over 48 hours using 0.9% NaCl
- Add 40 mmol/L KCl once urine output confirmed
- Switch to 0.45% NaCl + glucose 5% when BGL <14 mmol/L
Insulin
- Start 0.05–0.1 units/kg/hr after 1–2 hrs of fluid
- No insulin bolus in children
- Target BGL reduction: 2–5 mmol/L/hr
🫁 Bronchiolitis (RSV)
Diagnosis
- Age <12 months, first episode wheeze
- RSV most common (Oct–Mar in GCC); also Rhinovirus, hMPV
- Signs: tachypnoea, subcostal/intercostal recession, fine crackles, wheeze
Supportive Care (EVIDENCE-BASED)
- Nasal suctioning — frequent, especially before feeds
- O₂ to maintain SpO₂ ≥90–92%
- NG feeds if >30–40% increased work of breathing
- HFNC: first escalation for moderate-severe (2 L/kg/min)
- CPAP/BiPAP: if HFNC fails or severe apnoea
- Intubation: respiratory failure, recurrent apnoea
🧠 Bacterial Meningitis
Empirical Antibiotics (age-based)
| Age | Antibiotic | Dose |
|---|---|---|
| <3 months | Ampicillin + Cefotaxime | 200 mg/kg/day ÷ 6H |
| 3 mo – 18 yr | Ceftriaxone | 100 mg/kg/day ÷ 12H (max 4g/day) |
| Any age (MRSA risk) | + Vancomycin | 15 mg/kg Q6H |
Dexamethasone
- 0.15 mg/kg Q6H × 4 days
- Give 10–20 min BEFORE or with first antibiotic dose
- Greatest benefit: H. influenzae and pneumococcal meningitis
- Reduces hearing loss; less clear benefit for other organisms
LP Timing — Contraindications to Immediate LP
- GCS <9 or deteriorating conscious level
- Papilloedema / focal neurological signs
- Haemodynamic instability
- Coagulopathy (platelets <50, INR >1.5)
- Skin infection over LP site
CSF Interpretation
| WCC | Protein | Glucose | |
|---|---|---|---|
| Bacterial | >1000 PMN | ↑↑ | ↓ (<50% serum) |
| Viral | 10–500 lymph | Normal/↑ | Normal |
| TB | 100–500 lymph | ↑↑↑ | ↓↓ |
🦴 Intraosseous (IO) Access — EZ-IO
Sites (preferred order)
- Proximal tibia: 2 cm below tibial tuberosity, medial flat surface (most common in children)
- Distal tibia: Proximal to medial malleolus (alternative)
- Proximal humerus: Greater tubercle — preferred in adults; used in older children
- Distal femur: Neonates/infants if tibia inaccessible
Needle Sizes (EZ-IO)
- Pink (15 mm): 3–39 kg
- Blue (25 mm): ≥40 kg or obese smaller patient
- Yellow (45 mm): excessive tissue depth
Contraindications
- Fracture ipsilateral to insertion site
- Previous IO in same bone within 24 hrs
- Overlying infection or burn
- Osteogenesis imperfecta
- Prosthetic limb
🩸 Arterial Line in Small Patients
Sites
- Radial artery: First choice; Allen's test first (or pulse ox on thumb)
- Femoral artery: Emergency, large vessel; monitor for ischaemia
- Dorsalis pedis / posterior tibial: Alternative in infants
- Umbilical artery: Neonates only; UAC
Catheter Size
- Neonates: 24G
- Infants/toddlers: 22G
- Children: 20–22G
Maintenance
- Heparinised flush (1–2 units/mL NS), continuous at 1–3 mL/hr
- Zero transducer at mid-axillary line (4th ICS)
- Check limb perfusion hourly — colour, CRT, temperature
- Site change every 5–7 days or at first sign of concern
💙 PICC Line Care
Insertion Considerations
- Confirm tip position at cavoatrial junction on X-ray
- Measure arm circumference before insertion (oedema monitoring)
- Single-lumen preferred in children unless dual access critical
Daily Care Bundle (CLABSI prevention)
- Hand hygiene (5 moments)
- Assess line necessity every shift — remove if not needed
- CHG 2% dressing change every 7 days (or if wet/soiled)
- Scrub the hub × 15 sec before each access
- Closed needleless system; blood cultures before starting antibiotics
- Maintain dressing integrity; document in care plan
📊 Pain & Sedation Assessment
FLACC Scale (0–10) — Non-Verbal / Intubated
| Domain | 0 | 1 | 2 |
|---|---|---|---|
| Face | No expression | Occasional grimace | Frequent frown/clenched jaw |
| Legs | Normal/relaxed | Uneasy/restless | Kicking/drawn up |
| Activity | Lying quietly | Squirming/tense | Arched/rigid/jerking |
| Cry | No cry | Moans/whimpers | Crying steadily |
| Consolability | Content/relaxed | Reassurable | Inconsolable |
COMFORT-B Sedation Scale
Scores 6 domains (alertness, calmness, respiratory, crying, movement, muscle tone). Score 6–10 = over-sedated; 11–22 = optimal; 23–30 = under-sedated. Reassess Q4H.
NRS Scale
Numeric Rating Scale (0–10) for children ≥6 years who can self-report. Use Wong-Baker FACES for age 3–6.
🧠 Continuous EEG (cEEG) Monitoring in PICU
Indications
- Refractory status epilepticus
- Post-cardiac arrest (therapeutic hypothermia)
- Hypoxic-ischaemic encephalopathy (HIE)
- Encephalitis / meningitis with altered consciousness
- Post-neurosurgery with seizure risk
- Unexplained altered consciousness
- Metabolic encephalopathy (hyperammonaemia)
Nursing Responsibilities
- Apply electrodes according to 10-20 system (or 10-10 in neonates)
- Document clinical events with EEG annotations
- Minimise movement artefact — note suction, procedures
- Notify neurologist of electrographic seizures
- Monitor electrode integrity every 4 hours
- Integrate EEG findings with clinical status in handover
🏥 Major Paediatric Hospitals in GCC
| Hospital | Location | Notes |
|---|---|---|
| Batterjee Children's Hospital (BCH) | Riyadh, KSA | Tertiary paediatric centre; large PICU; cardiac surgery |
| National Guard Health Affairs – Paeds | Riyadh, KSA | Integrated paediatric services; PICU & NICU |
| Sheikh Khalifa Medical City (SKMC) | Abu Dhabi, UAE | Tertiary PICU; ECMO program; cardiac PICU |
| Al Jalila Children's Specialty Hospital | Dubai, UAE | Dubai's first dedicated children's hospital; Level III PICU |
| Al Wasl Hospital – Paediatrics | Dubai, UAE | General paediatrics; lower-acuity admissions; step-down |
| Hamad Medical Corp – Women's & Neonatal | Doha, Qatar | Largest NICU in Qatar; paediatric emergency |
| Salmaniya Medical Complex | Manama, Bahrain | National referral centre for paediatrics |
| Khoula Hospital | Muscat, Oman | Tertiary surgical centre; paediatric trauma PICU |
🧬 Genetic Conditions Prevalent in GCC
Consanguinity rates 20–60% in GCC → markedly elevated autosomal recessive disease prevalence
Inborn Errors of Metabolism (IEM)
- Phenylketonuria (PKU) — screened neonatally in all GCC states
- Maple Syrup Urine Disease (MSUD) — encephalopathy, sweet urine odour
- Urea Cycle Disorders (OTC deficiency) — hyperammonaemia, coma
- Organic Acidaemias (MMA, PA, IVA) — metabolic acidosis, ketonuria
- Fatty Acid Oxidation Disorders (MCAD) — hypoketotic hypoglycaemia
- Glycogen Storage Diseases — hepatomegaly, hypoglycaemia
Congenital Heart Disease
- Higher prevalence than global average in Arabian Peninsula
- VSD, ToF, TGA, HLHS common in PICU referrals
- Post-cardiac surgery patients: monitor SVC, PA pressures; pulmonary hypertensive crisis risk
Haematological
- Sickle Cell Disease — SCA crisis, acute chest syndrome, stroke
- Beta-Thalassaemia major — chronic transfusion, iron overload
- G6PD deficiency — haemolysis with oxidant exposure
👩⚕️ PICU Staffing Ratios — GCC Standards
| Country | Nurse:Patient Ratio | Physician Cover |
|---|---|---|
| Saudi Arabia (MOH) | 1:1 (ventilated); 1:2 (stable) | Resident 24/7; Intensivist consultant cover |
| UAE (DOH/DHA) | 1:1–2 per acuity | Fellow 24/7; Attending consultant on-call |
| Qatar (HMC) | 1:1 (ventilated) | Board-certified intensivist 24/7 in-house |
| Kuwait (MOH) | 1:2 standard | Senior resident + consultant cover |
| Bahrain | 1:2 (varies) | Consultant on-call 24/7 |
| Oman | 1:1–2 | Resident in-house; consultant reachable |
🚁 PICU Transport to Tertiary Centre
Stabilise Before Transport ("STABLE" Mnemonic)
- S — Sugar (BGL 4–8 mmol/L)
- T — Temperature (36.5–37.5°C)
- A — Airway (secure ETT; confirm position; CXR)
- B — Blood pressure (stable; vasopressors drawn up)
- L — Lab work (sent and reviewed)
- E — Emotional support (family briefed; consent taken)
Transport Team Minimum
- Paediatric transport nurse (PICU-trained)
- Physician (paediatric registrar minimum)
- Transport equipment: portable ventilator, defibrillator, infusion pumps, drug kit
- Pre-alert receiving PICU ≥30 min before arrival
🕌 Family Visiting in PICU — Cultural Expectations (GCC)
Visiting Practices
- Extended family involvement is normative — expect multiple family members
- Family spokesperson (usually father/elder male) for major decisions
- Mothers often wish to stay 24/7 — accommodate where safe
- Prayer times (5×/day) — schedule procedures around if possible
- Quran recitation at bedside — welcome and normalise
Communication Considerations
- Use certified medical interpreters for Arabic-speaking families
- Avoid delivering bad news in busy corridors
- Privacy for family discussions — dedicated family room
- Allow family to seek second opinions — facilitate this
- Discuss prognosis sensitively; avoid blunt prognostic statements
End-of-Life Care
- Withdrawal of care: sensitive; involves religious guidance (imam)
- Brain death: must be certified by two senior physicians; family may request time
- Post-mortem: often declined for religious reasons; respect this
- Ensure same-gender nurse where possible for personal care
- Facilitate family time and privacy at end of life
WETFLAG Emergency Calculator
Enter patient weight to auto-calculate all WETFLAG parameters. If weight unknown, estimate using (Age+4)×2 for 1–10 years.
Paediatric Drug Dose Calculator
Select a drug and enter weight to calculate recommended dose, max dose, and administration notes.