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GCC Nursing Education Series

Paediatric Diabetes Nursing Guide

Comprehensive clinical reference for T1DM & T2DM in children — DKA management, insulin therapy, CGM/pump technology, and GCC-specific practice. Aligned with BSPED, ISPAD & SCFHS exam requirements.

T1DM & T2DM DKA Protocol CGM & Pumps GCC Context SCFHS Exam Prep

Type 1 Diabetes Mellitus (T1DM)

  • Pathophysiology: Autoimmune destruction of pancreatic beta-cells. T-cell mediated with genetic susceptibility.
  • HLA Associations: HLA-DR3 and HLA-DR4 confer highest risk. HLA-DQ2/DQ8 also implicated.
  • Peak Onset Ages: Bimodal: 5–7 years (school entry) and 10–14 years (puberty). Puberty-related insulin resistance accelerates.
  • DKA at Diagnosis: ~30% of children present in DKA. Higher rates in younger children and minority populations.

The Classic 4 T's

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TOILET
Polyuria / polydipsia — frequent urination, excessive thirst
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THIRSTY
Polydipsia — may drink unusual volumes overnight
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TIRED
Lethargy, fatigue, decreased concentration at school
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THINNER
Weight loss — despite eating, catabolism of fat & muscle
Red Flag: DKA symptoms — vomiting, abdominal pain, Kussmaul breathing, altered consciousness. Immediate A&E attendance.

Diagnostic Criteria

Random Blood Glucose
>11.1 mmol/L
+ symptoms of hyperglycaemia
Fasting Plasma Glucose
>7.0 mmol/L
Fasting = no caloric intake >8 hours
2-hour OGTT
>11.1 mmol/L
After 75g glucose load (T2DM/MODY screening)
Autoantibodies (T1DM)
Anti-GAD65 • Islet Cell Ab (ICA) • IA-2 • ZnT8 • Insulin Ab (IAA)
Positive antibodies confirm autoimmune aetiology. Two or more significantly increases T1DM risk.

T2DM in Children & MODY

T2DM in children is rising rapidly in GCC — strongly linked to childhood obesity, sedentary lifestyle, and genetic predisposition.

Clinical Features:
  • Acanthosis nigricans (dark velvety skin folds — neck/axillae)
  • PCOS in adolescent girls
  • Strong family history (often 1st degree relative)
  • Overweight/obese (BMI >85th centile)
  • Screen all obese children >10 years (or puberty onset if earlier)
MODY — Maturity Onset Diabetes of the Young
  • Suspect if: negative antibodies, strong family history (autosomal dominant), mild stable hyperglycaemia
  • MODY2 (GCK): mild fasting hyperglycaemia, no treatment needed
  • MODY3 (HNF1A): responds to sulfonylurea, progressive
  • Diagnosis: genetic testing. Misdiagnosis as T1DM common — critical to identify for correct management
GCC Nurse Paediatric Diabetes Guide • Based on BSPED, ISPAD & NICE guidelines • Always refer to local protocols
BSPED 2021 ISPAD 2022 SCFHS Aligned