GCC Clinical Reference — Evidence-based Practice
Pupils Equal, Round, Reactive to Light
| Defect | Likely Site |
|---|---|
| Central scotoma | Macula / optic nerve |
| Bitemporal hemianopia | Optic chiasm (pituitary) |
| Homonymous hemianopia | Optic tract / occipital lobe |
| Inferior altitudinal | Superior retinal/CRAO branch |
| Arcuate scotoma | Glaucoma (nerve fibre layer) |
| Structure | What to Note |
|---|---|
| Optic disc | Cup:disc ratio (>0.6 suspicious), pallor, swelling, haemorrhage |
| Vessels | AV nipping, silver wiring, flame haemorrhages, BRVO/CRVO |
| Macula | Drusen (AMD), macular oedema, cherry-red spot, CSME |
| Periphery | Lattice degeneration, tears, detachment, neovascularisation |
| Class | Example | Mechanism | Key Side Effects / Nursing Points |
|---|---|---|---|
| Prostaglandin analogues | Latanoprost 0.005% 1st line |
↑ uveoscleral outflow | Iris pigmentation (irreversible), lash growth, periorbital fat atrophy. Once daily at night. Do not refrigerate after opening. |
| Beta-blockers | Timolol 0.25 / 0.5% Betaxolol |
↓ aqueous production | Systemic effects: bradycardia, bronchospasm, depression, masking hypoglycaemia. Contraindicated in asthma, COPD, heart block. Punctal occlusion essential. |
| Carbonic anhydrase inhibitors (CAI) | Dorzolamide (topical) Acetazolamide (oral/IV) |
↓ aqueous production | Topical: stinging, metallic taste. Oral: metabolic acidosis, renal stones, Stevens-Johnson (rare). Avoid in sulfa allergy. |
| Alpha-2 agonists | Brimonidine 0.1–0.2% | ↓ aqueous production, ↑ outflow | Allergy/follicular conjunctivitis (up to 15%). AVOID in children <2: CNS depression, apnoea. Drowsiness in elderly. |
| Rho kinase inhibitor | Netarsudil 0.02% | ↑ trabecular outflow | Conjunctival hyperaemia, cornea verticillata. Once daily. Newer class. |
| Drug | Use | Duration | Key Nursing Points |
|---|---|---|---|
| Tropicamide 1% | Mydriasis for fundoscopy | 4–6 hours | Driving warning: patient must NOT drive for duration. Can precipitate angle-closure in predisposed eyes. Document pre-dilation VA and IOP if indicated. |
| Cyclopentolate 1% | Cycloplegia (refraction in children) | 12–24 hours | Systemic toxicity in children (flushing, tachycardia, behavioural). Use 0.5% in neonates. |
| Phenylephrine 2.5 / 10% | Mydriasis (sympathomimetic) | 3–5 hours | 10% contraindicated in CVD, hypertension. Use 2.5% in elderly, neonates, cardiac patients. |
| Chloramphenicol 0.5% | Bacterial conjunctivitis, minor infections | 5–7 days | Rare aplastic anaemia (1:400,000). First-line OTC in many countries. Avoid in neonates (grey baby syndrome risk with systemic absorption). |
| Ciprofloxacin 0.3% | Corneal ulcer, severe infections | 2–3 weeks for ulcer | Broad-spectrum fluoroquinolone. Intense initial regimen: q1h day 1, then taper. White corneal precipitates may form (resolves). |
| Prednisolone 0.5–1% | Uveitis, post-operative inflammation | Weeks–months | IOP monitoring essential: steroid-responder IOP rise in ~35% (usually within 4–6 weeks). Also risk of posterior subcapsular cataract with prolonged use. Never use in active herpetic keratitis. |
| Drop | Frequency | Duration |
|---|---|---|
| Antibiotic (e.g. levofloxacin) | QDS | 2 weeks |
| Steroid (prednisolone 1%) | QDS → taper | 4 weeks |
| NSAID (ketorolac 0.5%) | QDS | 4 weeks |
| Alkali (worse) | Acid | |
|---|---|---|
| Examples | Lime, cement, bleach, ammonia | Battery acid, pool chemicals |
| Mechanism | Saponification → deep penetration | Protein coagulation → self-limiting |
| Severity | Higher; may perforate globe | Generally less severe |
| Feature | Preseptal (periorbital) | Orbital (post-septal) |
|---|---|---|
| Proptosis | Absent | Present Red Flag |
| EOM restriction/pain | Absent | Present |
| Visual loss | Absent | Possible — optic nerve compression |
| Chemosis | Absent | Often present |
| Systemic | Mild fever | High fever, unwell |
| Imaging | Clinical diagnosis | CT orbit with contrast urgently |
| Treatment | Oral co-amoxiclav | IV antibiotics + surgical drainage if abscess |
| Condition | Key Sign | Immediate Action |
|---|---|---|
| Open globe injury | Teardrop pupil, uveal prolapse, positive Seidel test | Metal shield (NO pressure); NPO; IV antibiotics; surgical repair |
| Hyphaema | Blood in anterior chamber | Bed rest at 30–45°; avoid aspirin/NSAIDs; IOP monitoring |
| Retinal detachment | Curtain/floaters/flashes | Same-day referral; keep macula-on if possible |
| Giant cell arteritis | Age >50, ESR/CRP↑, jaw claudication, scalp tenderness | IV methylprednisolone 1 g immediately; temporal artery biopsy within 2 weeks |
| Endophthalmitis | Post-op pain, hypopyon, vision loss | Same-day vitreous tap + intravitreal vancomycin/ceftazidime |