🩺 What is Central Venous Access?
Central venous catheters (CVCs) are large-bore catheters inserted into a central vein — subclavian, internal jugular (IJV), or femoral — with the catheter tip positioned at the superior vena cava (SVC) or SVC-right atrial junction. They are essential in critical care for delivering therapies that cannot be given peripherally.
Key Tip: Catheter tip should sit at the lower third of the SVC or the SVC-RA junction. Placement inside the right atrium (RA) risks arrhythmias and is UNACCEPTABLE.
📋 Types of Central Venous Catheters
| Type | Description | Typical Use | Duration |
| Non-tunnelled CVC | Subclavian, IJV, femoral — bedside insertion | Acute ICU, emergency fluids, vasopressors | Short-term (<2 weeks) |
| PICC Line | Peripherally inserted (antecubital) — tip at SVC | IV antibiotics, TPN, chemotherapy | Weeks to months |
| Tunnelled CVC (Hickman) | Tunnelled under skin — cuff reduces infection | Long-term TPN, chemotherapy, haemodialysis | Months to years |
| Implanted Port | Totally implanted under skin — accessed via needle | Oncology, intermittent IV therapy | Years |
| Dialysis Catheter | Large bore (11-14Fr), dual lumen | Haemodialysis, CRRT | Short or tunnelled |
✅ Indications for Central Venous Access
Haemodynamic
- CVP monitoring
- Vasopressor infusion (noradrenaline, dopamine)
- Rapid large-volume resuscitation
- Haemodialysis / CRRT
Therapeutic
- Total parenteral nutrition (TPN)
- Chemotherapy administration
- Long-term IV antibiotics
- No suitable peripheral access
📍 Site Selection — Infection Risk
| Site | Infection Risk | Notes |
| Subclavian | LOWEST | Preferred for long-term; higher pneumothorax risk |
| Internal Jugular (IJV) | Intermediate | Common in ICU; USS guidance preferred |
| Femoral | HIGHEST | Last resort only; high DVT + CLABSI risk |
| PICC | Low | Preferred for long-term non-ICU use |
Exam Alert: Subclavian = lowest CLABSI risk. Femoral = highest CLABSI risk. This is a favourite exam question.
🔍 Pre-Insertion Assessment
Patient Assessment
- Coagulation status — INR, platelet count (INR <1.5, Plt >50×10⁹ preferred)
- Allergy history (chlorhexidine, latex, contrast)
- Previous CVC history — site complications, thrombosis
- Bilateral upper limb assessment for PICC eligibility
- Anatomical considerations — obesity, neck surgery, mastectomy
USS Guidance
NICE guidelines recommend real-time ultrasound guidance for IJV insertion and strongly recommend for all non-emergency CVC placements. USS reduces failed attempts and arterial puncture risk.
📷 Post-Insertion Confirmation
MANDATORY: Chest X-ray (CXR) is required after EVERY non-tunnelled CVC insertion before clinical use. The CXR confirms:
- Catheter tip position — lower third SVC / SVC-RA junction
- Absence of pneumothorax
- Absence of haemothorax
- Correct line trajectory (not in subclavian artery)
Optimal tip position: lower third SVC or SVC-RA junction (approximately at the level of the carina on CXR).
Tip in right atrium: risk of cardiac arrhythmias — line must be withdrawn.
🌡️ Ongoing Assessment of CVC
- Daily line review: Is the line still necessary? Remove if no longer needed.
- Insertion site: Inspect for redness, swelling, discharge, tenderness
- Dressing integrity: Is dressing intact, dry, and adherent?
- Line patency: Flush each lumen — assess for resistance
- Signs of CLABSI: Fever, chills, rigors, hypotension without another source
- Catheter days: Document insertion date and calculate catheter days
Blood cultures: If CLABSI suspected, draw 2 sets of blood cultures — one from the CVC and one peripheral — before starting antibiotics.
🛡️ CLABSI Prevention Bundle (EPIC Bundle)
The CLABSI prevention bundle (also called the central line bundle or EPIC bundle) consists of 5 evidence-based elements that MUST all be implemented together — bundle compliance means ALL 5 elements present:
- Hand Hygiene — WHO 5 moments; surgical hand scrub for insertion
- Maximal Sterile Barrier Precautions — sterile gown, gloves, mask, cap + large sterile drape
- Chlorhexidine Gluconate Skin Preparation — 2% CHG in 70% isopropyl alcohol; allow to dry fully
- Optimal Site Selection — avoid femoral; prefer subclavian
- Daily Review of Line Necessity — remove line as soon as no longer needed
Key Fact: DHA and DOH in the UAE mandate CLABSI bundle compliance. JACHO-accredited GCC hospitals must track CLABSI rates as a mandatory patient safety indicator.
🩹 CVC Dressing Management
| Dressing Type | Change Frequency | Notes |
| Transparent (Tegaderm/IV3000) | Every 7 days | Standard; allows site inspection |
| Gauze dressing | Every 48 hours | Use only if site oozing or patient diaphoretic |
| Any dressing — if soiled/lifted/wet | Immediately | Do not wait for scheduled change |
CHG-impregnated dressings (e.g., Biopatch/Tegaderm CHG) are recommended in high-risk patients — reduce CLABSI rates by up to 60%.
💉 Line Flushing and Lumen Care
- Flush with 0.9% NaCl before and after each use (10 mL minimum)
- Use pulsatile (push-pause) technique to create turbulent flow and clear deposits
- Heparin lock only if policy states — some institutions use saline lock
- Use needleless connectors — clean with 15-second scrub before access
- Positive pressure technique on withdrawal to prevent blood reflux
🔄 Line Removal
- Position patient supine or Trendelenburg (prevents air embolism on removal)
- Ask patient to hold breath / perform Valsalva during removal of non-tunnelled CVC
- Apply firm pressure to site for minimum 5 minutes (longer if coagulopathic)
- Cover with occlusive dressing for 24 hours
- Send catheter tip for MC&S if CLABSI suspected
After removal of IJV or subclavian CVC: keep patient supine for at least 30 minutes and reassess for air embolism signs.
⚠️ Immediate / Insertion Complications
| Complication | Frequency | Signs | Management |
| Pneumothorax | Most common immediate | SOB, decreased breath sounds, tracheal deviation | Confirm CXR; needle decompression / chest drain |
| Haemothorax | Uncommon | SOB, dull percussion, haemodynamic instability | Chest drain; surgical if massive |
| Arterial Puncture | ~1-2% | Pulsatile bright red blood, pressure rise | Remove needle/catheter; apply firm pressure |
| Arrhythmia | Common (transient) | ECG changes, VEs, AF | Withdraw wire/catheter; usually resolves |
| Air Embolism | Rare but fatal | Hypotension, mill-wheel murmur, respiratory distress | See below |
💨 Air Embolism — Critical Response
Air embolism is a life-threatening emergency where air enters the venous system and obstructs right ventricular outflow.
Prevention
- Trendelenburg position during insertion (head down 15-30°) — increases venous pressure
- Valsalva manoeuvre during line insertion/removal — increases intrathoracic pressure
- Occlusive dressings; cap all open ports
Treatment
Emergency Position: Left Lateral Decubitus (Durant's manoeuvre) + Trendelenburg
This traps air in the apex of the right ventricle, preventing it from entering the pulmonary outflow tract. Aspirate air via CVC if possible. 100% O₂ to accelerate nitrogen reabsorption.
🦠 CLABSI — Catheter-Related Bloodstream Infection
CLABSI is defined as a primary bloodstream infection in a patient with a central line in place for >48 hours with no other identifiable source.
Common Organisms
- Coagulase-negative staphylococci (most common overall)
- Staphylococcus aureus (including MRSA)
- Candida species (immunocompromised)
- Gram-negatives (Klebsiella, Pseudomonas)
Nursing Actions on Suspected CLABSI
- Notify medical team immediately
- Draw blood cultures (CVC + peripheral) before antibiotics
- Document catheter days, insertion site, dressing changes
- Prepare for line removal and tip culture
- Complete incident report / CLABSI surveillance form
🩸 Late Complications
- Central vein thrombosis — especially PICC lines; unilateral arm swelling; treat with anticoagulation
- Catheter occlusion — fibrin sheath, drug precipitation; treat with alteplase instillation
- Catheter fracture / embolisation — fragments may migrate to heart/pulmonary vasculature; requires IR retrieval
- Extravasation — vesicant drugs (chemotherapy) can cause tissue necrosis
- Pinch-off syndrome — PICC/subclavian compressed between clavicle and 1st rib