Definition: Impaired myocardial perfusion despite successful mechanical opening of the epicardial coronary artery. Microvascular obstruction persists.
Presentation: ST changes after stenting, chest pain, haemodynamic deterioration despite TIMI 3 flow on angiography
Causes: Distal embolisation of plaque/thrombus, microvascular spasm, reperfusion injury, pre-existing microvascular disease
Treatment:
- Intracoronary adenosine: 100–200 mcg bolus (vasodilation)
- Intracoronary verapamil: 100–200 mcg (calcium channel blocker)
- Intracoronary nitroprusside: alternative vasodilator
- GP IIb/IIIa inhibitor (abciximab): if thrombus burden high
- Support haemodynamics: IABP or Impella if cardiogenic shock develops
⚠Nurse role: prepare intracoronary medications rapidly; monitor haemodynamics continuously; alert team to BP/HR changes.
Recognition: Generalised urticaria, bronchospasm, angioedema, hypotension, cardiovascular collapse. Onset: seconds to minutes after contrast injection.
Risk factors: Previous anaphylaxis to contrast, shellfish allergy (iodine association debated), asthma, multiple allergies
Emergency Treatment:
- STOP contrast immediately
- Adrenaline (epinephrine) 0.5mg IM (anterolateral thigh / deltoid)
- Call for help — activate resuscitation team
- High-flow oxygen 15 L/min (non-rebreather mask)
- IV fluids: 500–1000mL 0.9% NaCl bolus for hypotension
- Chlorphenamine 10mg IV slow + hydrocortisone 200mg IV
- Salbutamol nebuliser if bronchospasm
- Repeat adrenaline every 5 minutes if no improvement